Article

Multi-omics characterization of vascular, neurodegenerative, and mixed neuropathology in the aging human brain

2026-03-18

Abstract excerpt

Late-life cognitive impairment most commonly occurs in the setting of mixed neurodegenerative and cerebrovascular pathology, yet the molecular programs distinguishing vascular, neurodegenerative, and mixed pathology in the aging human brain remain incompletely defined. We performed neuropathology-stratified proteomic and transcriptomic profiling of postmortem brain tissue from participants in the Religious Orders...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3c79c006-1f87-5ce3-a9db-1070be1322ca
DOI: 10.64898/2026.03.17.712511

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-omics characterization of vascular, neurodegenerative, and mixed neuropathology in the aging human brainDOI 10.64898/2026.03.17.712511Read

Integration of aged brain multi-omics reveals cross-system mechanisms underlying Alzheimer’s disease heterogeneitySemantic proximity Read

Identification of conserved proteomic networks in neurodegenerative dementiaSemantic proximity Read

Unbiased classification of the elderly human brain proteome resolves distinct clinical and pathophysiological subtypes of cognitive impairmentSemantic proximity Read

Systemic infections alter cortical transcriptionalsignatures in Alzheimer’s diseaseSemantic proximity Read

Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer’s diseaseSemantic proximity Read

A mitochondrial-immune axis drives the transcriptomic transition from brain aging to Alzheimer’s diseaseSemantic proximity Read

Proteomic Subtyping of Alzheimer’s Disease CSF links Blood-Brain Barrier Dysfunction to Reduced levels of Tau and Synaptic BiomarkersSemantic proximity Read

Brain cross-omics integration in Alzheimer’s diseaseSemantic proximity Read

Proteomic profiling of Alzheimer’s disease and Vascular dementia reveals unique underlying signaturesSemantic proximity Read

Balanced deep learning on multi-omics networks identifies molecular subgroups of pathological brain agingSemantic proximity Read

Transcriptomic profiling of the middle temporal gyrus reveals differential glial/neuronal dysregulation across Alzheimer’s disease and agingSemantic proximity Read

Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA levelSemantic proximity Read