Aged brain multi-omic integration captures immunometabolic and sex variation

Abstract excerpt

<h4>SUMMARY</h4> Resolving the molecular basis for heterogeneous ageing in the human brain requires integrating its diverse molecular layers. Here we applied a tensor-decomposition framework to jointly analyse single-nucleus RNA-seq, DNA methylation, H3K9ac histone acetylation and proteomic data from 276 post-mortem human cortices. The analysis uncovered two dominant, multi-omic themes. First, we identified an im...

Topics

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• Alzheimer Disease
• Alzheimer's disease research and treatments
• Bioinformatics and Genomic Networks
• Diet and metabolism studies
• Epigenetics and DNA Methylation
• Genetic Associations and Epidemiology
• Genetic Predisposition to Disease
• Metabolomics and Mass Spectrometry Studies

Identifiers and source

Literature Corpus work

6143a1b4-5838-5da9-9591-3d719e97e14d

DOI

10.1101/2025.10.10.681695