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Divergent transcriptomic transition programs in Alzheimer disease: immune priming and synaptic collapse in females versus organelle membrane bifurcation in males

2026-07-13

Abstract excerpt

Alzheimer’s disease (AD) disproportionately affects women, who account for approximately two-thirds of prevalent cases. Despite decades of research, the mechanistic basis for this profound sex disparity remains poorly resolved. Prior transcriptomic studies have predominantly used pooled or female-enriched cohorts, obscuring whether the transition from normal cognition (NCI) to AD follows a common molecular program...

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Literature Corpus work
1bb4dea2-d6ec-573e-8c27-198eb6d814bc
DOI
10.64898/2026.07.09.735789
Open publication

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Divergent transcriptomic transition programs in Alzheimer disease: immune priming and synaptic collapse in females versus organelle membrane bifurcation in malesDOI 10.64898/2026.07.09.735789
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