Article

Microglia produce the amyloidogenic ABri peptide in familial British dementia

2023-06-28

Abstract excerpt

Mutations in ITM2B cause familial British, Danish, Chinese and Korean dementias. In familial British dementia (FBD) a mutation in the stop codon of the ITM2B gene (also known as BRI2 ) causes a C-terminal cleavage fragment of the ITM2B/BRI2 protein to be extended by 11 amino acids. This fragment, termed amyloid-Bri (ABri), is highly insoluble and forms extracellular plaques in the brain. ABri plaques are accomp...

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Literature Corpus work: 916ea599-f68a-54b0-9e2b-52c051c5e2e2
DOI: 10.1101/2023.06.27.546552

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