Article
BRI2 (ITM2b) inhibits Abeta deposition in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Jun 2008
Kim Jungsu, Miller Victor M, Levites Yona, West Karen Jansen, Zwizinski Craig W, Moore Brenda D, Troendle Fredrick J, Bann Maralyssa, Verbeeck Christophe, Price Robert W, Smithson Lisa, Sonoda Leilani, Wagg Kayleigh, Rangachari Vijayaraghavan, Zou Fanggeng, Younkin Steven G, Graff-Radford Neill, Dickson Dennis, Rosenberry Terrone, Golde Todd E
Abstract excerpt
Analyses of the biologic effects of mutations in the BRI2 (ITM2b) and the amyloid beta precursor protein (APP) genes support the hypothesis that cerebral accumulation of amyloidogenic peptides in familial British and familial Danish dementias and Alzheimer's disease (AD) is associated with neurodegeneration. We have used somatic brain transgenic technology to express the BRI2 and BRI2-Abeta1-40 transgenes in APP...
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