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Candidate-based screening via gene modulation in human neurons and astrocytes implicatesFERMT2in Aβand TAU proteostasis

25 Oct 2018

Abstract excerpt

Large-scale 'omic' studies investigating the pathophysiological processes that lead to Alzheimer's disease (AD) dementia have identified an increasing number of susceptibility genes, many of which are poorly characterized and have not previously been implicated in AD. Here, we evaluated the utility of human induced pluripotent stem cell-derived neurons and astrocytes as tools to systematically test AD-relevant...

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PMID: 30371777
DOI: 10.1093/hmg/ddy376

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