Article

BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer’s disease and related dementias

2023-06-14

Abstract excerpt

ITM2B/BRI2 mutations cause familial forms of Alzheimer’s disease (AD)-related dementias by disrupting BRI2’s protein function and leading to the accumulation of amyloidogenic peptides. Although typically studied in neurons, our findings show that BRI2 is highly expressed in microglia, which are crucial in AD pathogenesis due to the association of variants in the microglial gene TREM2 with increased AD risk. Our si...

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Literature Corpus work: 977fc16e-1ecf-5854-9e0a-a1547a19d990
DOI: 10.1101/2023.06.14.544924

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