Article

Generating human parvalbumin interneurons through 3D glia reprogramming

2024-09-10

Abstract excerpt

<h4>Summary</h4> Parvalbumin (PV) interneurons are crucial for synaptic plasticity, and their damage or loss is linked to various neurological disorders. Yet, generating these cells of human source in vitro is challenging, limiting advancements in cell repair and disease modelling. We introduce a novel approach to derive human PV neurons through direct reprogramming of glial precursor cells (GPCs). Using ectopic...

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Literature Corpus work: 914b8871-23a0-54ed-bb70-8cba3bad8e53
DOI: 10.1101/2024.09.06.609855

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