Article

Dlx2 reprograms the transcriptome and laminar position of glia-derived Ascl1-induced interneurons

2026-01-02

Abstract excerpt

<h4>ABSTRACT</h4> Direct lineage reprogramming of glial cells into neurons offers a promising strategy to repair diseased brain circuits, but engineering defined neuronal subtypes remains challenging. We found that a phospho-site-deficient Ascl1 variant, Ascl1SA6, but not wildtype Ascl1, induces hallmarks of parvalbumin fast-spiking interneurons, raising the question of how closely these induced neurons resemble...

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Literature Corpus work: cd473b6a-0609-52ca-a8b1-3af622fce24e
DOI: 10.64898/2026.01.02.697435

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