Article

Human stem cell-derived GABAergic interneuron development reveals early emergence of subtype diversity followed by gradual electrochemical maturation

2024-12-04

Abstract excerpt

<h4>SUMMARY</h4> Medial ganglionic eminence-derived inhibitory GABAergic pallial interneurons (MGE-pINs) are essential regulators of cortical circuits; their dysfunction is associated with numerous neurological disorders. We developed human (h) MGE-pINs from pluripotent stem cells for the treatment of drug-resistant epilepsy. Here, we analyzed xenografted hMGE-pINs over the lifespan of host mice using single nucl...

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Literature Corpus work: 1b24b03d-2e4b-5c5c-9f36-d9b1a35b9724
DOI: 10.1101/2024.12.03.626662

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