Article

Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics

2020-01-08

Abstract excerpt

Comparative transcriptomics between differentiating human pluripotent stem cells (hPSC) and developing mouse neurons offers a powerful approach to compare genetic and epigenetic pathways in human and mouse neurons. To analyze human Purkinje cell (PC) differentiation, we optimized a protocol to generate hPSC-PCs that formed synapses when cultured with mouse cerebellar glia and granule cells and fired large calcium...

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Literature Corpus work: 779ee617-7d2f-5cfe-81dd-fdc261fca163
DOI: 10.1101/2020.01.07.897371

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