Article

Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic Activity

2021-01-25

Abstract excerpt

Variations in tumor biology from patient to patient combined with the low overall survival rate of hepatocellular carcinoma (HCC) present significant clinical challenges. During the progression of chronic liver diseases from inflammation to the development of HCC, microenvironmental properties, including tissue stiffness and oxygen concentration, change over time. This can potentially impact drug metabolism and su...

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Literature Corpus work: 912c4b24-ce1c-566c-8b39-db58ef002c14
DOI: 10.1101/2021.01.23.427874

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