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Article

Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma.

Journal of experimental & clinical cancer research : CR - 25 May 2018

Song Yeonhwa, Kim Jin-Sun, Kim Se-Hyuk, Park Yoon Kyung, Yu Eunsil, Kim Ki-Hun, Seo Eul-Ju, Oh Heung-Bum, Lee Han Chu, Kim Kang Mo, Seo Haeng Ran

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and has poor prognosis. Specially, patients with HCC usually have poor tolerance of systemic chemotherapy, because HCCs develop from chronically damaged tissue that contains considerable inflammation, fibrosis, and cirrhosis. Since HCC exhibits highly heterogeneous molecular characteristics, a proper in vitro system is...

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Share to Carcinoma, Hepatocellular
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Drug Screening Assays, Antitumor

Share to Liver Neoplasms

Share to Primary Cell Culture

Share to Spheroids, Cellular

Share to Tumor Cells, Cultured

Source

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Identifiers

PMID: 29801504
DOI: 10.1186/s13046-018-0752-0
PMCID: PMC5970513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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