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Time-course characterization of whole-transcriptome dynamics of HepG2/C3A spheroids and its toxicological implications

3 Oct 2024

Abstract excerpt

Physiologically relevant in vitro models are a priority in predictive toxicology to replace and/or reduce animal experiments. The compromised toxicant metabolism of many immortalized human liver cell lines grown as monolayers as compared to in vivo metabolism limits their physiological relevance. However, recent efforts to culture liver cells in a 3D environment, such as spheroids, to better mimic the in vivo...

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PMID: 39368564
DOI: 10.1016/j.toxlet.2024.10.004

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