Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of hypoxia and oxidative stress on proteo-metabolomic alterations of 3D cholangiocarcinoma models

21 Feb 2023

Abstract excerpt

The three-dimensional multicellular spheroid (3D MCS) model has been employed in cholangiocarcinoma research as it generates 3D architecture and includes more physiological relevance with the multicellular arrangement. However, it is also essential to explain the molecular signature in this microenvironment and its structural complexity. The results indicated that poorly differentiated CCA cell lines were unable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36810897
DOI: 10.1038/s41598-023-30204-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of hypoxia and oxidative stress on proteo-metabolomic alterations of 3D cholangiocarcinoma modelsPMID 36810897Read ↗

Multifaceted Aspects of Metabolic Plasticity in Human Cholangiocarcinoma: An Overview of Current PerspectivesSemantic proximity Read ↗

Changes in Protein Expression in Two Cholangiocarcinoma Cell Lines Undergoing Formation of Multicellular Tumor Spheroids In VitroSemantic proximity Read ↗

Identification of serum metabolite biomarkers and metabolic reprogramming mechanisms to predict recurrence in cholangiocarcinomaSemantic proximity Read ↗

Role of Glucose Metabolism Reprogramming in the Pathogenesis of CholangiocarcinomaSemantic proximity Read ↗

Primary Liver Cancers: Connecting the Dots of Cellular Studies and Epidemiology with MetabolomicsSemantic proximity Read ↗

Comprehensive analysis of transcriptome and metabolome analysis in Intrahepatic Cholangiocarcinoma and Hepatocellular CarcinomaSemantic proximity Read ↗

Single-cell Multi-omics reveal heterogeneity and metastasis potential in different liver cancer cell linesSemantic proximity Read ↗

Multi-omics-driven discovery of invasive patterns and treatment strategies in CA19-9 positive intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Lactic acidosis induces metabolic and phenotypic reprogramming in cholangiocarcinoma cells via the upregulation of thrombospondin-1.Semantic proximity Read ↗

Metabolomic markers of colorectal tumor with different clinicopathological featuresSemantic proximity Read ↗

Analysis of metabolite characteristics and signaling pathways in head and neck cancer based on metabolomicsSemantic proximity Read ↗

Integrative multiomics analysis identifies molecular subtypes and potential targets of hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.