Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response

28 Oct 2024

Abstract excerpt

Background & Aims: Hepatocellular carcinoma (HCC) is the third-leading and fastest rising cause of cancer-related death worldwide. The discovery and preclinical development of compounds targeting HCC are hampered by the absence of authentic tractable systems recapitulating the heterogeneity of HCC tumors in patients and the tumor microenvironment (TME). Methods: We established a novel and simple patient-derived...

Topics

Join the communities discussing this publication.

Cancer Cells and Metastasis
Immune cells in cancer
Mathematical Biology Tumor Growth

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39897611
DOI: 10.1016/j.jhepr.2024.101252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A patient-derived HCC spheroid system to model the tumor microenvironment and treatment responsePMID 39897611Read ↗

Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma.Semantic proximity Read ↗

Modelling hepatocellular carcinoma microenvironment phenotype to evaluate drug efficacy.Semantic proximity Read ↗

Organoids and spheroids: advanced in vitro models for liver cancer researchSemantic proximity Read ↗

Spheroids in cancer research: Recent advances and opportunitiesSemantic proximity Read ↗

Generating Patient-Derived HCC Cell Lines Suitable for Predictive In-Vitro and In-Vivo Drug Screening by Orthotopic TransplantationSemantic proximity Read ↗

Establishment of a hepatocellular carcinoma patient‐derived xenograft platform and its application in biomarker identificationSemantic proximity Read ↗

Development of a Multicellular 3D Tumor Model to Study Cellular Heterogeneity and Plasticity in NSCLC Tumor MicroenvironmentSemantic proximity Read ↗

Cellular heterogeneity and plasticity in liver cancerSemantic proximity Read ↗

Human liver organoids for disease modeling of fibrolamellar carcinomaSemantic proximity Read ↗

Sarcoma Spheroids and Organoids—Promising Tools in the Era of Personalized MedicineSemantic proximity Read ↗

Breaking the mold: 3D cell cultures reshaping the future of cancer researchSemantic proximity Read ↗

Patient-derived organoids in translational oncology and drug screeningSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.