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Article

Sorafenib Resistance in Hepatocellular Carcinoma: The Relevance of Genetic Heterogeneity

15 Jun 2020

Abstract excerpt

Despite advances in biomedicine, the incidence and the mortality of hepatocellular carcinoma (HCC) remain high. The majority of HCC cases are diagnosed in later stages leading to the less than optimal outcome of the treatments. Molecular targeted therapy with sorafenib, a dual-target inhibitor targeting the serine-threonine kinase Raf and the tyrosine kinases VEGFR/PDGFR, is at present the main treatment for...

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PMID: 32549224
DOI: 10.3390/cancers12061576

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