Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of Spheroidal Age on Sorafenib Diffusivity and Toxicity in a 3D HepG2 Spheroid Model

19 Mar 2019

Abstract excerpt

The enhanced predictive power of 3D multi-cellular spheroids in comparison to conventional monolayer cultures makes them a promising drug screening tool. However, clinical translation for pharmacology and toxicology is lagging its technological progression. Even though spheroids show a biological complexity resembling native tissue, standardization and validation of drug screening protocols are influenced by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3D Printing in Biomedical Research
Share to Cancer Cells and Metastasis
Share to Liver physiology and pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30890741
DOI: 10.1038/s41598-019-41273-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of Spheroidal Age on Sorafenib Diffusivity and Toxicity in a 3D HepG2 Spheroid ModelPMID 30890741Read ↗

Pre-clinical 2D and 3D Toxicity Response to A Panel of Nanomaterials; Comparative Assessment of NBM-Induced Liver ToxicitySemantic proximity Read ↗

Comparative Evaluation of the Cytotoxicity of Doxorubicin in BT-20 Triple-Negative Breast Carcinoma Monolayer and Spheroid CulturesSemantic proximity Read ↗

Mature tumoroids recapitulate clinically relevant drug response through extended 3D culture in PDACSemantic proximity Read ↗

Two-Dimensional and Spheroid-Based Three-Dimensional Cell Culture Systems: Implications for Drug Discovery in CancerSemantic proximity Read ↗

A Three-Dimensional Cell Culture Platform for Long Time-Scale Observations of Bio-Nano Interactions.Semantic proximity Read ↗

Phenotypic profiles for anticancer drug responses using tumor spheroids.Semantic proximity Read ↗

Inventions and Innovations in Preclinical Platforms for Cancer ResearchSemantic proximity Read ↗

Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic ActivitySemantic proximity Read ↗

Cell line-dependent effects of spheroid formation method on drug response in melanoma modelsSemantic proximity Read ↗

Time-course characterization of whole-transcriptome dynamics of HepG2/C3A spheroids and its toxicological implicationsSemantic proximity Read ↗

Micropatterned Co-Cultures of Human Hepatocytes and Stromal Cells for the Assessment of Drug Clearance and Drug-Drug Interactions.Semantic proximity Read ↗

Spheroids as a Type of Three-Dimensional Cell Cultures—Examples of Methods of Preparation and the Most Important ApplicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.