Article

Alcohol induces sorafenib resistance in hepatocellular carcinoma: A Translational Study

2025-07-01

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Alcohol is a major cause of hepatocellular carcinoma (HCC), accounting for 30% of cases worldwide. Sorafenib, a tyrosine kinase inhibitor (TKI), was the standard first-line treatment for advanced HCC until 2021, but sorafenib resistance is common. We explored the impact of chronic alcohol exposure (CAE) on sorafenib response and sought to identify associated...

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Literature Corpus work: bcd67af0-f15e-5f16-83f7-d9c8b165004f
DOI: 10.21203/rs.3.rs-6837338/v1

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