Article

Biological sex and age shape melanoma tumour evolution

2019-11-01

Abstract excerpt

Many cancer types display sex and age disparity in incidence and outcome. Here, we establish a mathematical approach using cancer mutational data to analyze how sex and age shape the tumour genome. We model how age-related (clock-like) somatic mutations that arise during cell division, and extrinsic (environmental) mutations accumulate in cancer genomes. As a proof-of-concept, we apply our approach to melanoma, a...

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Identifiers and source

Literature Corpus work: 91239b78-d5cc-51d7-98ad-ea5afaf94b9e
DOI: 10.1101/828038

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