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Article

Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2015

Rozhok Andrii I, DeGregori James

Abstract excerpt

Our understanding of cancer has greatly advanced since Nordling [Nordling CO (1953) Br J Cancer 7(1):68-72] and Armitage and Doll [Armitage P, Doll R (1954) Br J Cancer 8(1):1-12] put forth the multistage model of carcinogenesis. However, a number of observations remain poorly understood from the standpoint of this paradigm in its contemporary state. These observations include the similar age-dependent...

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Identifiers

PMID: 26195756
DOI: 10.1073/pnas.1501713112
PMCID: PMC4517250

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Source receipt: pubmed, retrieved 7 Sept 2026.

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