Article
Cancer as a disease of old age: changing mutational and microenvironmental landscapes.
British journal of cancer - 1 Mar 2020
Laconi Ezio, Marongiu Fabio, DeGregori James
Abstract excerpt
Why do we get cancer mostly when we are old? According to current paradigms, the answer is simple: mutations accumulate in our tissues throughout life, and some of these mutations contribute to cancers. Although mutations are necessary for cancer development, a number of studies shed light on roles for ageing and exposure-dependent changes in tissue landscapes that determine the impact of oncogenic mutations on...
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