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Article

A generalized theory of age-dependent carcinogenesis

29 Apr 2019

Abstract excerpt

The Multi-Stage Model of Carcinogenesis (MMC), developed in the 1950 s-70s, postulated carcinogenesis as a Darwinian somatic selection process. The cellular organization of tissues was then poorly understood, with almost nothing known about cancer drivers and stem cells. The MMC paradigm was later confirmed, and cancer incidence was explained as a function of mutation occurrence. However, the MMC has never been...

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PMID: 31034356
DOI: 10.7554/elife.39950

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