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Article

The effect of age on the acquisition and selection of cancer driver mutations in sun-exposed normal skin.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Mar 2021

Hernando B, Dietzen M, Parra G, Gil-Barrachina M, Pitarch G, Mahiques L, Valcuende-Cavero F, McGranahan N, Martinez-Cadenas C

Abstract excerpt

BACKGROUND: The accumulation of somatic mutations contributes to ageing and cancer. Sunlight is the principal aetiological factor associated with skin cancer development. However, genetic and phenotypic factors also contribute to skin cancer risk. This study aimed at exploring the role of photoaging, as well as other well-known epidemiological risk factors, in the accumulation of somatic mutations in cancer-free...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

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Source

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Identifiers

PMID: 33307203
DOI: 10.1016/j.annonc.2020.11.023
PMCID: PMC7614988

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