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Article

Modelling the ageing dependence of cancer evolutionary trajectories.

Nature reviews. Cancer - 1 Oct 2025

Henry Curtis J, DeGregori James

Abstract excerpt

Ageing is the single most important prognostic factor for cancer development. Despite this knowledge, experimental models of cancer have historically omitted incorporating the impact of age on cancer initiation, progression and treatment outcomes. Ageing interacts with other lifestyle factors, including cigarette smoking, obesity and physical activity, but these intersections are rarely studied in experimental...

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PMID: 40640377
DOI: 10.1038/s41568-025-00838-3

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