Article

RNF43 mutations facilitate colorectal cancer metastasis via formation of a tumour-intrinsic niche

2022-12-23

Abstract excerpt

<h4>Summary</h4> In colorectal cancer (CRC), RNF43 mutations are linked to BRAF V600E-initiated serrated adenomas that advance into mucinous adenocarcinomas with poor prognosis upon metastasis. How RNF43 mutations facilitate a metastasis-prone growth state remains unknown. Here, we addressed this issue by repairing mutant RNF43 in patient-derived BRAF-mutant CRC organoids using gene editing. Upon RNF43 correc...

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Literature Corpus work: 910f3781-2b31-59b0-a56d-fa057292824b
DOI: 10.1101/2022.12.22.521159

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