Article

Paradoxical tumor suppressive role of the <i>musculoaponeurotic fibrosarcoma</i> gene in colorectal cancer

2022-08-26

Abstract excerpt

<h4>Summary</h4> Somatic cell reprogramming using the microRNAs miR200c, miR-302s, and miR-369s leads to increased expression of cyclin-dependent kinase inhibitors in human colorectal cancer (CRC) cells and suppressed tumor growth. Here, we investigated whether these microRNAs inhibit colorectal tumorigenesis in CPC;Apc mice, which are prone to colon and rectal polyps. Repeated administration of microRNAs inhibi...

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Literature Corpus work: 984737d2-9c79-5acd-9623-12d4bf3673dc
DOI: 10.1101/2022.08.25.505236

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