Article
A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis.
Cell stem cell - 2 Jun 2016
Fujii Masayuki, Shimokawa Mariko, Date Shoichi, Takano Ai, Matano Mami, Nanki Kosaku, Ohta Yuki, Toshimitsu Kohta, Nakazato Yoshihiro, Kawasaki Kenta, Uraoka Toshio, Watanabe Toshiaki, Kanai Takanori, Sato Toshiro
Abstract excerpt
Colorectal tumor is a heterogeneous disease, with varying clinical presentation and prognosis in patients. To establish a platform encompassing this diversity, we generated 55 colorectal tumor organoid lines from a range of histological subtypes and clinical stages, including rare subtypes. Each line was defined by gene expression signatures and optimized for organoid culture according to niche factor...
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