Article
Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers.
Oncogene - 1 Apr 2020
Li Shan, Lavrijsen Marla, Bakker Aron, Magierowski Marcin, Magierowska Katarzyna, Liu Pengyu, Wang Wenhui, Peppelenbosch Maikel P, Smits Ron
Abstract excerpt
Cancer-associated RNF43 mutations lead to activation of β-catenin signaling through aberrantly increasing Wnt-receptor levels at the membrane. Importantly, inactivating RNF43 mutations have been suggested to render cancer cells sensitive to Wnt-based therapeutics. However, the extent to which RNF43 mutations lead to impaired regulation of Wnt/β-catenin signaling has been poorly investigated. Here, we observed...
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