Article
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.
Gut - 1 Apr 2019
Lannagan Tamsin R M, Lee Young K, Wang Tongtong, Roper Jatin, Bettington Mark L, Fennell Lochlan, Vrbanac Laura, Jonavicius Lisa, Somashekar Roshini, Gieniec Krystyna, Yang Miao, Ng Jia Q, Suzuki Nobumi, Ichinose Mari, Wright Josephine A, Kobayashi Hiroki, Putoczki Tracey L, Hayakawa Yoku, Leedham Simon J, Abud Helen E, Yilmaz Ömer H, Marker Julie, Klebe Sonja, Wirapati Pratyaksha, Mukherjee Siddhartha, Tejpar Sabine, Leggett Barbara A, Whitehall Vicki L J, Worthley Daniel L, Woods Susan L
Abstract excerpt
OBJECTIVE: Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant and with worst outcomes. This CRC subtype is associated with activating mutations in the mitogen-activated kinase pathway gene, BRAF, and epigenetic modifications termed the CpG Island Methylator Phenotype, leading to epigenetic silencing of key tumour suppressor...
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