Article
RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation.
Gut - 1 Sept 2017
Yan Helen H N, Lai Jeffrey C W, Ho Siu Lun, Leung Wai Keung, Law Wai Lun, Lee Janet F Y, Chan Anthony K W, Tsui Wai Yin, Chan Annie S Y, Lee Bernard C H, Yue Sarah S K, Man Alice H Y, Clevers Hans, Yuen Siu Tsan, Leung Suet Yi
Abstract excerpt
OBJECTIVE: Serrated polyps (hyperplastic polyps, sessile or traditional serrated adenomas), which can arise in a sporadic or polyposis setting, predispose to colorectal cancer (CRC), especially those with microsatellite instability (MSI) due to MLH1 promoter methylation (MLH1me+). We investigate genetic alterations in the serrated polyposis pathway. DESIGN: We used a combination of exome sequencing and target...
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