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Article

Impact of loss-of-function mutations at the RNF43 locus on colorectal cancer development and progression.

The Journal of pathology - 1 Aug 2018

Eto Tsugio, Miyake Keisuke, Nosho Katsuhiko, Ohmuraya Masaki, Imamura Yu, Arima Kota, Kanno Shinichi, Fu Lingfeng, Kiyozumi Yuki, Izumi Daisuke, Sugihara Hidetaka, Hiyoshi Yukiharu, Miyamoto Yuji, Sawayama Hiroshi, Iwatsuki Masaaki, Baba Yoshifumi, Yoshida Naoya, Furukawa Toru, Araki Kimi, Baba Hideo, Ishimoto Takatsugu

Abstract excerpt

RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. Here, we investigated the clinical significance of RNF43 mutations in a large Japanese cohort and the role of RNF43 at various stages of colorectal cancer development and progression. Mutation analysis of the RNF43 gene locus with pyrosequencing technology detected RNF43 hotspot mutations...

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Source

Identifiers

PMID: 29756208
DOI: 10.1002/path.5098

Genes

RNF43

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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