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Article

A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

15 Sept 2020

Abstract excerpt

Frequent mutation of the tumour suppressor RNF43 is observed in many cancers, particularly colon malignancies. RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity requires phosphorylation at a triplet of conserved serines. This phospho-regulation of RNF43 is required for zebrafish development and...

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PMID: 32934222
DOI: 10.1038/s41467-020-18257-3

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