Article

Human Telomerase Expression is under Direct Transcriptional Control of the Telomere-binding-factor TRF2

2020-01-15

Abstract excerpt

Tight regulatory mechanisms to maintain repression of human Telomerase (hTERT), the sole protein that synthesizes telomeres, is crucial for normal adult somatic cells. In contrast, enhanced telomerase activity and resulting pathological maintenance of telomeres, is widely understood as causal in >90% of human cancers. These implicate underlying mechanisms connecting hTERT regulation and telomeres, possibly throug...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 90d8b17c-583f-5015-8c79-86df13b188c2
DOI: 10.1101/2020.01.15.907626

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Telomerase Expression is under Direct Transcriptional Control of the Telomere-binding-factor TRF2DOI 10.1101/2020.01.15.907626Read

Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interactionSemantic proximity Read

Abnormal function of telomere protein TRF2 induces cell mutation and the effects of environmental tumor‑promoting factors (Review).Semantic proximity Read

TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblastsSemantic proximity Read

TRF1 and TRF2: pioneering targets in telomere-based cancer therapySemantic proximity Read

The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage ResponseSemantic proximity Read

Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cellsSemantic proximity Read

TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancerSemantic proximity Read

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damageSemantic proximity Read

Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damageSemantic proximity Read

ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2Semantic proximity Read

In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2Semantic proximity Read

Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletionsSemantic proximity Read