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Article

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage

19 Nov 2016

Abstract excerpt

Telomere repeat binding factor 2 (TRF2) has been increasingly recognized to be involved in telomere maintenance and DNA damage response. Here, we show that TRF2 directly binds SIRT6 in a DNA independent manner and that this interaction is increased upon replication stress. Knockdown of SIRT6 up-regulates TRF2 protein levels and counteracts its down-regulation during DNA damage response, leading to cell survival....

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Share to Mitochondrial Function and Pathology
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Identifiers

PMID: 27923994
DOI: 10.1093/nar/gkw1202

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SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damagePMID 27923994Read ↗

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