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Article

In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2

9 Sept 2022

Abstract excerpt

RNA-protein interactions drive key cellular pathways such as protein translation, nuclear organization and genome stability maintenance. The human telomeric protein TRF2 binds to the long noncoding RNA TERRA through independent domains, including its N-terminal B domain. We previously demonstrated that TRF2 B domain binding to TERRA supports invasion of TERRA into telomeric double stranded DNA, leading to the...

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Identifiers

PMID: 36142374
DOI: 10.3390/ijms231810463

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2PMID 36142374Read ↗

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integritySemantic proximity Read ↗

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage.Semantic proximity Read ↗

The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loopsSemantic proximity Read ↗

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short TelomeresSemantic proximity Read ↗

TERRA long noncoding RNA: At the interphase of telomere damage, rescue and signalingSemantic proximity Read ↗

Functional characterization of the TERRA transcriptome at damaged telomeresSemantic proximity Read ↗

TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integritySemantic proximity Read ↗

R-Loops at Chromosome Ends: From Formation, Regulation, and Cellular ConsequenceSemantic proximity Read ↗

RBMX involves in telomere stability maintenance by regulating TERRA expressionSemantic proximity Read ↗

The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNASemantic proximity Read ↗

RTEL1 influences the abundance and localization of TERRA RNASemantic proximity Read ↗

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at TelomeresSemantic proximity Read ↗

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