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Article

Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells

7 Jun 2014

Abstract excerpt

Glioblastoma is the most prevalent primary brain tumor and is essentially universally fatal within 2 years of diagnosis. Glioblastomas contain cellular hierarchies with self-renewing glioblastoma stem cells (GSCs) that are often resistant to chemotherapy and radiation therapy. GSCs express high amounts of repressor element 1 silencing transcription factor (REST), which may contribute to their resistance to...

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PMID: 24909307
DOI: 10.1002/glia.22708

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