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TRF1 and TRF2: pioneering targets in telomere-based cancer therapy

16 Jul 2024

Abstract excerpt

This article presents an in-depth exploration of the roles of Telomere Repeat-binding Factors 1 and 2 (TRF1 and TRF2), and the shelterin complex, in the context of cancer biology. It emphasizes their emerging significance as potential biomarkers and targets for therapeutic intervention. Central to the shelterin complex, TRF1 and TRF2 are crucial in maintaining telomere integrity and genomic stability, their...

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PMID: 39012375
DOI: 10.1007/s00432-024-05867-3

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