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Article

TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer

28 Feb 2022

Abstract excerpt

The Telomeric Repeat binding Factor 2 (TRF2), a key protein involved in telomere integrity, is over-expressed in several human cancers and promotes tumor formation and progression. Recently, TRF2 has been also found outside telomeres where it can affect gene expression. Here we provide evidence that TRF2 is able to modulate the expression of microRNAs (miRNAs), small non-coding RNAs altered in human tumors. Among...

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Identifiers

PMID: 35240232
DOI: 10.1016/j.canlet.2022.215607

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