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Article

The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage Response

14 Sept 2021

Abstract excerpt

Telomere repeat binding factor 2 (TRF2) has a well-known function at the telomeres, which acts to protect the telomere end from being recognized as a DNA break or from unwanted recombination. This protection mechanism prevents DNA instability from mutation and subsequent severe diseases caused by the changes in DNA, such as cancer. Since TRF2 actively inhibits the DNA damage response factors from recognizing the...

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PMID: 34576063
DOI: 10.3390/ijms22189900

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