Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions

Abstract excerpt

The shelterin protein TRF2 is essential for chromosome-end protection. Depletion of TRF2 causes chromosome end-to-end fusions, initiating genomic instability that can be cancer promoting. Paradoxically, significant increased levels of TRF2 are observed in a subset of human cancers. Experimental overexpression of TRF2 has also been shown to induce telomere shortening, through an unknown mechanism. Here we report...

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• Share to Chromosomal and Genetic Variations
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