Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

Abstract excerpt

Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resulting erosion of telomeres leads eventually to replicative senescence. Reactivation of hTERT maintains telomeres and triggers progression of >90% of cancers. However, any direct causal link between telomeres and telomerase regulation remains unclear. Here, we show that the telomere-repeat-binding-factor 2 (TRF2)...

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• Share to Advanced biosensing and bioanalysis techniques
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• Share to Telomeres, Telomerase, and Senescence