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Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein

12 Apr 2018

Abstract excerpt

Tau antibodies have shown therapeutic potential for Alzheimer's disease and several are in clinical trials. As a microtubule-associated protein, tau relies on dynamic phosphorylation for its normal functions. In tauopathies, it becomes hyperphosphorylated and aggregates into toxic assemblies, which collectively lead to neurodegeneration. Of the phospho-epitopes, the region around Ser396 has received particular...

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PMID: 29670132
DOI: 10.1038/s41598-018-24276-4

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