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Article

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau.

Acta neuropathologica communications - 31 Jul 2017

Strang Kevin H, Goodwin Marshall S, Riffe Cara, Moore Brenda D, Chakrabarty Paramita, Levites Yona, Golde Todd E, Giasson Benoit I

Abstract excerpt

Tauopathies are a group of neurodegenerative disorders, including Alzheimer's disease, defined by the presence of brain pathological inclusions comprised of abnormally aggregated and highly phosphorylated tau protein. The abundance of brain tau aggregates correlates with disease severity and select phospho-tau epitopes increase at early stages of disease. We generated and characterized a series of novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28760159
DOI: 10.1186/s40478-017-0458-0
PMCID: PMC5537986

Genes

PHF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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