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Article

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti‐tau antibody AT8

22 Jan 2016

Abstract excerpt

Microtubule-associated protein tau becomes abnormally phosphorylated in Alzheimer's disease and other tauopathies and forms aggregates of paired helical filaments (PHF-tau). AT8 is a PHF-tau-specific monoclonal antibody that is a commonly used marker of neuropathology because of its recognition of abnormally phosphorylated tau. Previous reports described the AT8 epitope to include pS202/pT205. Our studies support...

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PMID: 26800003
DOI: 10.1002/prot.24988

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Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti‐tau antibody AT8PMID 26800003Read ↗

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