Article

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau

2020-01-06

Abstract excerpt

<h4>ABSTRACT</h4> The microtubule-associated protein Tau is implicated in the pathogenesis of several neurodegenerative disorders, including Alzheimer’s disease. Increasing evidence suggests that post-translational modifications play critical roles in regulating Tau normal functions and its pathogenic properties in Tauopathies. Very little is known about how phosphorylation of tyrosine residues influences the str...

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Literature Corpus work: 4a3032fc-321b-519c-87d9-f52d64f2a457
DOI: 10.1101/2020.01.06.896381

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