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Article

Structures of ΔD421 Truncated Tau Fibrils.

Journal of molecular biology - 15 May 2025

El Mammeri Nadia, Duan Pu, Hong Mei

Abstract excerpt

The microtubule-associated protein tau aggregates into pathological β-sheet amyloid fibrils in Alzheimer's disease (AD) and other neurodegenerative diseases. In these aggregates, tau is chemically modified, including abnormal hyperphosphorylation and truncation. Truncation after D421 in the C-terminal domain occurs at early stages of AD. Here we investigate the structures of ΔD421-truncated 0N4R tau fibrils...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40021051
DOI: 10.1016/j.jmb.2025.169051
PMCID: PMC12959921

Genes

PHF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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