Article

Cortical Parvalbumin-positive Interneuron Development and Function are Altered in the APC Conditional Knockout Mouse Model of Infantile Spasm Syndrome

2022-07-06

Abstract excerpt

Infantile Spasms syndrome (ISS) is a childhood epilepsy syndrome characterized by infantile or late onset spasms, abnormal neonatal EEG, and epilepsy. Few treatments exist for IS, clinical outcomes are poor, and the molecular and circuit-level etiologies of IS are not well understood. Multiple human ISS risk genes are linked to Wnt/β-catenin signaling, a pathway which controls developmental transcriptional program...

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Literature Corpus work: 909ba451-c4d1-5d1e-966f-787aa27c932a
DOI: 10.1101/2022.07.06.499046

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