Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cortical interneurons in autism.

Nature neuroscience - 1 Dec 2021

Contractor Anis, Ethell Iryna M, Portera-Cailliau Carlos

Abstract excerpt

The mechanistic underpinnings of autism remain a subject of debate and controversy. Why do individuals with autism share an overlapping set of atypical behaviors and symptoms, despite having different genetic and environmental risk factors? A major challenge in developing new therapies for autism has been the inability to identify convergent neural phenotypes that could explain the common set of symptoms that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autistic Disorder
Share to Interneurons
Share to Parvalbumins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 34848882
DOI: 10.1038/s41593-021-00967-6
PMCID: PMC9798607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cortical interneurons in autism.PMID 34848882Read ↗

Inhibitory control of the excitatory/inhibitory balance in psychiatric disordersSemantic proximity Read ↗

Identifying developing interneurons as a potential target for multiple genetic autism risk factors in human and rodent forebrainSemantic proximity Read ↗

Cortical Parvalbumin-positive Interneuron Development and Function are Altered in the APC Conditional Knockout Mouse Model of Infantile Spasm SyndromeSemantic proximity Read ↗

Whole-brain clearing reveals region- and cell type-specific imbalances in inhibitory neurons in a mouse model for Kleefstra SyndromeSemantic proximity Read ↗

The Role of Inhibitory Interneurons in Cortical Computation: Mechanisms, Functions, and Clinical ImplicationsSemantic proximity Read ↗

Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex.Semantic proximity Read ↗

Inhibitory interneurons of the human prefrontal cortex display conserved evolution of the phenotype and related genes.Semantic proximity Read ↗

Region-specific alterations of perineuronal net expression in postmortem autism brain tissueSemantic proximity Read ↗

Late onset and regional heterogeneity of synaptic deficits in cortical PV interneurons of <i> Shank3B <sup>−/−</sup> </i> miceSemantic proximity Read ↗

Cortical assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defectsSemantic proximity Read ↗

Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes.Semantic proximity Read ↗

Arid1b haploinsufficiency in parvalbumin- or somatostatin-expressing interneurons leads to distinct ASD-like and ID-like behavior.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.