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Article

APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures.

Neurobiology of disease - 1 Feb 2017

Pirone Antonella, Alexander Jonathan, Lau Lauren A, Hampton David, Zayachkivsky Andrew, Yee Amy, Yee Audrey, Jacob Michele H, Dulla Chris G

Abstract excerpt

Infantile spasms (IS) are a catastrophic childhood epilepsy syndrome characterized by flexion-extension spasms during infancy that progress to chronic seizures and cognitive deficits in later life. The molecular causes of IS are poorly defined. Genetic screens of individuals with IS have identified multiple risk genes, several of which are predicted to alter β-catenin pathways. However, evidence linking...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27852007
DOI: 10.1016/j.nbd.2016.11.002
PMCID: PMC5222689

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APC

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